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Boron compounds have been shown to facilitate epithelialization in various ways ( 7.2 Fibroblast proliferation and migration Fibroblasts are pivotal cells in wound healing, playing a crucial role in producing collagen and other extracellular matrix components, including fibronectin, glycosaminoglycans, proteoglycans, and hyaluronic acid, which are vital for tissue repair and regeneration (Tottoli et al., 2020)

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Klotho deficiency in CKD accelerates cognitive decline, whereas exercise-induced factors such as irisin might have a protective effect on brain health