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We further addressed how the GSH changes are related to clinical features
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On the other hand, NRF2 inhibitors (ML385 (a direct Neh1 domain binder with an IC 50 of 1.9 μM) [91] and Nrf2-IN-1 [92]) induce apoptosis in cancer cells carrying mutations in the KEAP1-NRF2 axis by restricting the availability of oxidative stress protector proteins
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