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The activated Kupffer cells produce several cytokines and growth factors such as tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), platelet derived growth factor (PDGF), and interleukin (IL)−1β which in turn activate and transform the quiescent HSCs into myofibroblast like cells 99,100,101
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L-glutamine enhances tight junction integrity by activating camk kinase 2–amp-activated protein kinase signaling in intestinal porcine epithelial cells
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