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As physical disruption of the ECM microstructures in vivo is characteristic of liver fibrosis, the discoveries presented here which showcase how microstructures modulate glutathione metabolism demonstrate a novel link between the physical ECM and cell metabolism

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The article also points out that a deficiency of glutathione contributes to oxidative stress, which may make the body more susceptible to diseases like Alzheimer’s, Parkinson’s, cancer, stroke, cystic fibrosis and diabetes