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Due to the EPR effect, nanocarriers with a particle size of less than 200 nm can easily penetrate the tumor vasculature system, resulting in passive targeting, which produces therapeutic effects in the tumor tissue

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Depending on the dysregulation of the PI3K/AKT pathway (overactivation or inhibition) in a specific disease state, TSA can recalibrate pathway activity to a physiological equilibrium point by modulating its upstream and downstream molecular network, thereby alleviating the pathological process in a targeted manner (99,111,121)