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This effect has been seen with 5-FU and oxaliplatin chemotherapies, through knock down of aquaporin-5 and MMP7 respectively (37, 125, 126)
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Two species, hydrogen peroxide (H 2 O 2 ) and the superoxide anion radical (O 2 ·− ), are key redox signalling agents generated under the control of growth factors and cytokines by more than 40 enzymes, prominently including NADPH oxidases and the mitochondrial electron transport chain
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