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In order to begin to assess the clinical potential of dihexa as an anti-dementia drug we chose to evaluate its effects on a more physiological relevant model- the aged Sprague Dawley rat

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Although these reports are largely anecdotal, clinical observations indicate that elderly obese patients generally tolerate HBOT comparably to younger adults, without a higher incidence of adverse effects—aside from issues such as blood pressure regulation [113] and middle ear barotrauma, which require monitoring in older individuals because of vascular stiffness and Eustachian tube rigidity [114,115]