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Specifically, this interaction represses the transcription of cytochrome C oxidase II (COX2), NADH: Ubiquinone oxidoreductase core subunit 3 (ND3) and cytochrome B (CYTB) genes encoded at the mitochondrial level (43)
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In AD, a progressive neurodegenerative disorder, disruptions in energy metabolism contribute to the gradual degeneration and apoptosis of neuronal cells in the brain, ultimately causing severe cognitive impairment
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