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Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Peng et al., 2016)

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B12 deficiency causes the formation of abnormal red blood cells resulting in megaloblastic anemia, characterized by large, immature red blood cells, leading to inefficient oxygen transport and symptoms like fatigue and weakness [1,8]