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Hydration and urinary alkalinization may be necessary to prevent the precipitation of methotrexate and/or its metabolites in the renal tubules

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It is a heterodimeric cell surface amino acid transporter formed by the light chain, the 12-transmembrane transporter solute carrier family 7 member 11 (SLC7A11) ( 2.3 Mitochondrial drive for lipid peroxidation Ferroptosis's defining hallmark is iron-dependent lipid peroxidation at the plasma membrane, driven by GPX4 inactivation and glutathione depletion, with mitochondrial changes often observed as secondary features

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