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In Prp-TDP-43 A315T mice, dysregulated expression of estrogen-related enzymes (CYP19A1 and CYP3A4) was observed relative to wild-type controls, which suggested that toxic phosphorylated TDP-43 oligomers may disrupt the balance between CYP19A1 and CYP3A4 expression, resulting in reduced estrogen biosynthesis and accelerated degradation

ingredient-phosphatidylcholine

Size:30 ml // 1 fl oz

Quick spin at 700 rpm and remove supernatant containing unbound proteins (this can be kept for further analysis)