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(Note: in some very specific cases and under certain conditions in some algae and mushrooms, there may be certain active fractions, but these are very small amounts that have not been shown to be useful or viable as strategies, and analogues may still be present)

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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome