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From a clinical perspective, emphysema-dominant patients may be more likely to exhibit mitochondrial damage and ferroptosis susceptibility features, chronic bronchitis or frequent exacerbation patients may lean toward an inflammasome/pyroptosis active state, and those with significant exercise intolerance, sarcopenia, or metabolic abnormalities may be closer to the extrapulmonary mitochondrial failure phenotype (136)

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The Defective Allele of Aldehyde Dehydrogenase 2 Gene is Associated with Favorable Postoperative Prognosis in Hepatocellular Carcinoma