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In the duodenum, this freed vitamin B12 combines with intrinsic factor (IF), a transport and delivery binding protein secreted by the stomach’s parietal cells and this complex is absorbed in the distal ileum by cubum receptor-mediated endocytosis

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416,417 Detailed information of acute liver failure and acute-on-chronic liver failure managements can be found in updated AASLD and EASL clinical practice guidelines (Fig