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Ancestral and local adaptation contribute to dispersal out of the Qinghai–Tibet Plateau in a bumblebee | PNAS
This is due to oxidative stress, which is characterized by increased free-radicals and impaired antioxidant capacity
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Together, these structural and biochemical results demonstrate that DCAF11 recognizes and binds GSH or glutathionylated molecules, and reveal how GSH-M12 hijacks this evolutionary conserved GSH-binding ligase to facilitate degradation of DDX18
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