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In published in vitro and preclinical research, IGF-1 LR3 has been studied in connection with binding to the IGF-1 receptor (IGF-1R) and reduced affinity for IGF-binding proteins (IGFBPs), and with downstream signaling pathways including PI3K/Akt and MAPK/ERK

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Each of the features (i.e., focal thickening of the alveolar membranes, congestion, pulmonary edema, intra-alveolar hemorrhage, interstitial neutrophil infiltration, and intra-alveolar neutrophil infiltration) was scored (0–3) as absent (0) or present to a mild (1), moderate (2), or severe (3) degree, and a final histology score was determined