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Frontiers | Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

These enzymes are critical for maintaining normal mitochondrial metabolism and, when combined with Cu ions, lead to the accumulation of lipoylated proteins and mitochondrial metabolic dysfunction [20, 28]

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Data are presented as number of patients or median (range) values