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Early clinical trials indicated minimal activity, primarily because the drug couldn’t penetrate the blood-brain barrier (BBB) effectively and because the tumor growth wasn’t largely dependent on the targeted pathway ( Lapatinib, a dual inhibitor of EGFR and human epidermal growth factor receptor 2 (HER2), is the most frequently tested EGFR inhibitor in GB trials
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Mitochondrial genome (mtDNA) mutations that generate reactive oxygen species
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