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Radiation is delivered as external beam radiation, using high-energy photons, protons, or particle rays, or as internal radiation, placing radioactive substances directly into tumors (Baskar et al., 2012)

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This promotes Epithelial-Mesenchymal Transition (EMT) by disrupting PER2 function and promoting early metastasis in breast cancer resulting in poor prognosis of the patients (Nakamura et al., 2001)