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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Viader A., Sasaki Y., Kim S., Strickland A., Workman C.S., Yang K., Gross R.W., Milbrandt J
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The pathways that increase ROS are alcohol metabolism caused by ADH and ALDH changing the cells’ redox state, hypoxia associated with alcohol metabolism, activation of CYP2E1 metabolism at higher alcohol concentrations, acetaldehyde formation, depletion of antioxidants (cytosolic GSH and mGSH), mitochondrial damage, and activation of Kupffer cells (31)
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