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The extent and clinical significance of this effect remain subjects of ongoing investigation, and individual responses vary considerably based on genetic factors affecting pigmentation, baseline skin characteristics, concurrent skincare practices and sun exposure, and overall health status affecting skin appearance
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Recently, the antipruritic effect of curcumin was found to be mediated through the Mas-related G-protein-coupled receptor B2 (MRGPRB2), the rodent homolog of the human MRGPRX2, as demonstrated by inhibition of C48/80-induced calcium influx in mouse peritoneal MC in a concentration-dependent manner
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