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Inflammatory M1 macrophages also exhibit distinct iron-handling features, including increased expression of ferritin (FtH, FtL) and hepcidin, coupled with reduced FPN1, promoting intracellular iron retention (95, 107, 108)
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Rapamycin treatment, and resulting inhibition of mTORC2, reduced the phosphorylation and activity of several PKC isozymes, in particular PKCβ, and ameliorated mitochondrial disease and neuropathology in a mouse model of Leigh syndrome (Martin‐Perez et al., 2020)
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