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Furthermore, the NNMT SNP rs694539 increases risk of acute lymphoblastic leukemia ( NNMT is expressed mainly in the liver and adipose tissue, and a small amount of NNMT can be detected in the kidney, lung, skeletal muscle, and the heart ( NNMT expression is altered in metabolic diseases such as obesity and cirrhosis (35)
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Misfolded or mutated alpha-synuclein has been suggested to result in dysregulated vesicle recycling through PLD2 related mechanisms, leading to reduced number of vesicles available for dopamine storage [250]
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