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These cells build up a protein called FOXO4

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Necropsy findings show diffuse neutrophilic infiltration and alveolar hemorrhage in the lungs, in addition to leukemia infiltration in several organs.59–60 Clinically, DS presents as dyspnea, pulmonary infiltrate on X-ray, fever, pleural or pericardial effusion, acute renal failure, hypotension, weight gain and edema.53 Infectious and cardiac etiologies must be ruled out, but if suspected, treatment must be initiated promptly