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In a phase I study conducted in Japan including 12 human participants (20–36 years), daily consumption of 100 g fresh broccoli sprouts was shown to improve HDL by 7.6% in female participants and reduce total cholesterol by 10% in male participants from baseline measurements ( Neurological and Psychiatric Disorders Preclinical evidence suggests that glucosinolates and their metabolites, particularly sulforaphane, exhibit several biological properties that may be relevant to neurological and psychiatric conditions ( α , and increasing IL-10) ( Psychiatric Disorders Due to the supportive mechanistic data, animal models and clinical trials have begun to evaluate the use of sulforaphane interventions for psychiatric outcomes, including depression, schizophrenia, and autism ( These results are supported by a recent randomized placebo controlled trial, which demonstrated that a 6-week sulforaphane intervention (30 mg/day) safely improved depressive symptoms, as measured by the Hamilton Rating Scale for Depression, in 66 participants with a history of a cardiac procedure and presence of mild to moderate depression ( n = 10) open label study demonstrated that an 8-week sulforaphane intervention improved cognitive function in a cohort of participants with schizophrenia ( n = 58) reported that sulforaphane (approximately 45 mg/day) failed to change the severity of psychotic symptoms compared to placebo using the total Positive and Negative Syndrome Scale ( Neurological Disorders Similar to psychiatry, various animal models have suggested the efficacy of sulforaphane interventions in the treatment of neurodegenerative disease

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Some observational studies have reported associations, but these studies are difficult to interpret because people usually take acetaminophen for a reason (including fever, infection, inflammation, or pain) and those underlying conditions can influence outcomes too