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Many compounds that look excellent in rodents fail in human trials because of differences in physiology, dosing, absorption, injury complexity, and the messy realities of chronic conditions
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Absorption of human calcitonin in rats was significantly increased by co-administration with surfactants, such as sodium myristate, sodium deoxycholate, sodium taurodeoxycholate, sodium lauryl sulfate, quillaja saponin, and sugar esters
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