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The main molecular mechanisms involved in the modulation of eryptosis studied to date, including intracellular calcium levels, ceramide, ROS, NO, changes in cellular energy metabolism, PS externalization, ion channel regulation, Fas-mediated signaling pathways, kinase-associated, and caspases activation, among others represent potential targets for inducing or inhibiting erythrocyte death
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For instance, PET studies with 15 O-oxygen and related tracers can offer direct physiological measurement of circulatory parameters of regional blood flow and vascular volume (178)
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