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The formation of MG-H1 in proteins replaces a hydrophilic, positively charged arginine residue with an uncharged, hydrophobic MG-H1 residue and thereby produces misfolding and activation of the unfolded protein response (UPR) [6,7]
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In cell culture, we found that ( S )-dHTC1 potently and stereoselectively suppressed the growth of ENL-dependent MV4;11 cells but did not impact ENL-insensitive HL-60 cells (Fig
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