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Frontiers | Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer

It highlights recent evidence that alcohol induces a cascade of reactive oxygen species (ROS)-mediated lipid peroxidation and nicotinamide adenine dinucleotide (NAD + ) depletion, triggering mitochondrial dysfunction and metabolic imbalances in the liver, heart, pancreas, and brain

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In summary, mitochondrial-associated inflammation is increasingly recognised as a central axis in ovarian ageing, encompassing diverse interlinked mechanisms such as energy metabolism dysregulation, oxidative stress, inflammatory activation, and epigenetic reprogramming