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NADPH and Glutathione Redox Link TCA Cycle Activity to Endoplasmic Reticulum Homeostasis: iScience

Together, these findings establish the SMG1/DNA-PK–NRF2 axis as an early redox-responsive signaling module that enables adaptive antioxidant responses under limited oxidative stress, while revealing a stress–intensity–dependent signaling hierarchy that governs the transition from redox adaptation to ferroptotic cell death

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[DOI] [PMC free article] [PubMed] [Google Scholar] 207.Stenberg G., Board P.G., Mannervik B