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Biosynthesis of unnatural γ-glutamyl cysteine analogues We found that γ-glutamyl phosphate (synthesized in vitro by ProB(supp)) reacts selectively with thiol containing amino acids l-Cys and l-Hcys (homocysteine), but not with l-Ser or any amino acid lacking a thiol group (Supplementary Table 3 online)
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The defection of mitophagy will lead to the accumulation of dysfunctional mitochondria, resulting in the leakage of Cytc into the cytoplasm to induce the activation of the caspase signaling pathway, and contribute to cell death (Sinha et al., 2013
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