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Glossary Rel A v-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A p50 NF-κB pro subunit COX-2 Cyclooxygenase-2 iNOS Inducible Nitric Oxide Synthase ICAM-1 Intercellular Adhesion Molecule-1 MCP-1 Monocyte Chemoattractant Protein-1 MP-1 MEK Partner 1 IP-10 Interferon gamma-induced protein 10 TNF-α Tumour Necrosis Factor-α IL-1β Interleukin 1 beta IL-16 Interleukin 16 GPCR G-Protein Coupled Receptor GWF Glycogen 6-phosphate dehydrogenase growth factor GBR2 GABA Receptor Subunit beta-2 RAS Rat Sarcoma (family of small GTPase protein) RAF Rapidly Accelerated Fibrosarcoma A-RAF A-Rapidly Accelerated Fibrosarcoma B-RAF B-Rapidly Accelerated Fibrosarcoma MPK Mitogen Activated Protein Kinase MEK1/2 MAPK/ERK kinase 1 and 2 ERK1/2 Extracellular Signal-Regulated Kinase 1 and 2 MAP3K Mitogen activated protein kinase MAP2K Mitogen activated protein kinase MAPK Mitogen Activated Protein Kinase TRAF-2 TNF Receptor associated factor-2 MAP3K4 Mitogen-Activated Protein Kinase 3-4 MAP3K12 Mitogen-Activated Protein Kinase 3-12 MKK MAPK Kinase MEKK1/4/7 MAPK/ERK kinase 1, 4 and 7 JNK1/2/3 c-Jun N-terminal kinase 1, 2 and 3 Bcl B-cell lymphoma J Bcl variant of Bcl omi omi/HtrA2 (Apoptosis protease) Smac Second mitochondria derived activator of caspases clp-1 Claspin 1 casp8 Caspase 8 casp7 Caspase 7 casp3 Caspase 3 ATF-2 Activating Transcription factor 2 AP1 Activator Protein 1 TCF T-cell Factor ELK ETS-like protein STAT Signal Transducer and Activator of Transcription c-JUN cellular-JUN c-MYC cellular-MYC MyD88 Myeloid differentiation primary response 88 IRAK-1 Interleukin-1 Receptor associated kinase 1 TRAF6-INF Receptor Associated Factor 6 TAB TAK1-binding protein ASK1 Apoptosis Signal-regulating kinase 1 TAK1 Transforming growth factor-β-Activated kinase-1 PI3K Phosphoinositide-3-kinase MKK-4/3/6 MAPK kinase 4, 3 and 6 p38α p38 α MAPK p110 Catalytic subunit of PI3K T306 Threonine 306 (phosphorylation site) S473 Serine 473 TSC1/2 Tuberous sclerosis complex 1 and 2 mTORC2 Mechanistic Target of Rapamycin Complex 2 Rheb Ras homolog enriched in brain p70S6K p70 Ribosomal S6 kinase 4EBP-1 Eukaryotic Translation Initiation Factor 4E-binding protein EIF4E Eukaryotic Translation Initiation Factor 4E MDM2 Mouse-Double Minus 2 homolog (E3 ubiquitin protein ligase) XIAP X-linked Inhibitor of Apoptosis Protein FOXO Forkhead box O Bcl2 B-cell lymphoma 2 SARA SMAD Anchor for Receptor Activation SMAD2 SMAD family member 2 SMAD3 SMAD family member 3 SMAD4 SMAD family member 4 TGF-βT €Transforming Growth Factor-beta Receptor ROS Reactive Oxygen Species RNS Reactive Nitrogen Species ABC Transporter ATP-binding cassette transporter P-gp ATPase P-glycoprotein ATPase Tyr Tyrosine TFR1 Transferrin Receptor-1 TF Transferrin DMT1 Divalent Metal Ion Transporter TCA cycle Tricarboxylic Acid cycle STEAP3 Six Transmembrane Epithelial Antigen of the Prostate 3 DFO Deferoxamine NCOA4 Nuclear Receptor Coactivator 4 GSH Glutathione DLAT Dihydrolipoamide Acetyltransferase RBX1 RING-box Protein 1 Cul3 Cullin 3 KEAP1 Kelch-like ECH-associated Protein 1 Nrf2 Nuclear-Factor Erythroid 2-related Factor 2 Smaf Small Maf Protein ARE Antioxidant Response Element GSK3β Glycogen Synthase Kinase 3 β B-TrCP Beta-Transducin Repeat Containing Protein Cul1 Cullin 1 Ub Ubiquitin HO-1 Heme Oxygenase-1 NQO-1 NAD(P)H-Quinone Oxidoreductase 1 GSLS Glycosphingolipids PSTs Protein sulfotransferase TAK1 TGF-β Activated kinase 1 IRS Insulin Receptor Substrate MK2 Mitogen Activated Protein Kinase-Activated Protein Kinase 2 MK3 Mitogen Activated Protein Kinase-Activated Protein Kinase 3 HSP27 Heat shock protein 27 PRAK1 p38-Regulated/Activated Kinase 1 MSK-1 Mitogen-and Stress-Activated Protein Kinase 1 ChG-8 protein code CHOP/C/EBP Homologous Protein MEF Myocyte Enhanse Factor MKK2/3 Mixed-lineage Kinase 2 and 3 RAC Ras-related (3 botulinum toxin substrate) CDC42 cell division cycle 42 CD-45 Region 45 JAK Janus kinase PTPS Protein-Tyrosine Phosphatase SOCS Suppressors of Cytokine Signals PIAS Protein Inhibitors of Activated STAT MCL7 Myeloid Cell Leukemia-1 VEGF-2 Vascular Endothelial Growth Factor Receptor-2 PAMP Pathogen Associated Molecular Pattern DAMP Damage Associated Molecular Pattern ILIRI Interleukin 1 Receptor Type 1 P2X7R P2X7 Receptor LPS Lipopolysaccharides SIRT2 Sirtuin 2 NLRP3 NOD-, LRR- and Pyrin Domain-containin Protein 3 ASC Apoptosis-Associated Speck-like Protein containing a CARD NEK-7 NIMA-related kinase 7 GISDMD Gasdermin D GISDMD-NT Gasdermin DN-terminal domain AKT Protein Kinase B PIP3/2 Phosphatidylinositol (3,4,5) p85 Regulatory subunit of p85 of PI3K Acknowledgements The authors acknowledge the Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India, for providing a fellowship

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2:482, the sequence identity alignment algorithm of Needleman and Wunsch, 1970, J