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Coupling to Gαi/o suppresses adenylate cyclase, decreases cyclic adenosine monophosphate (cAMP) levels [120], and reduces extracellular signal-regulated kinase (ERK) activity [121], which can limit extracellular signal-regulated kinase (ERK)-driven pro-inflammatory transcription [117]
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Mammals express seven isoforms (SIRT1–SIRT7), sharing a conserved catalytic core but differing in terminal domains, which confer distinct functions
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