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Hyperglycemia in patients treated with immune checkpoint inhibitors: key clinical challenges and multidisciplinary consensus recommendations | Journal for ImmunoTherapy of Cancer

Thus, future studies need to identify the genes responsible for GSH biosynthesis and the cellular mechanisms underlying the regulation of enzymes related to GSH metabolism or degradation

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Since our experiments demonstrate an effect in the short term, it is unlikely that drastic changes in transcriptional activity and therefore in enzyme quantities (such as methionine synthase or cysteine synthase complex) are involved—although we recognize that the transcription of genes encoding adenosine 5′‐phosphosulfate reductase (APR) can vary significantly within 2 h, as shown for the dark-to-light transition 38