oxygen dependent intracellular killing ros production glutathione Pathophysiology of reactive species (ROS) single-40

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TGFβ induces the translocation of the SMAD2–SMAD3 complex of transcription factors into the nucleus, where it directly promotes the expression of ECM genes such as COL1A1, COL3A1 and TIMP1 , as well as about 60 other ECM-related genes 78

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Androgens are produced by the innermost zona reticularis, which aids in the development of secondary sexual characteristics (13) ( Figure 1 )