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Pathogenesis R2 The pathophysiology of this alteration of iron metabolism regulation seems to be triggered by lipotoxicity in the presence of permissive environmental and genetic determinants, but additional studies are required to clarify the contribution of subclinical inflammation and the underlying mechanisms and implications (U)

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Numerous symptoms of normal pregnancy coincide with those of endocrine disorders, and pregnancy itself modifies baseline biochemical parameters ( 3 Critical windows of inflammatory cytokine expression in pregnancy IL-1β and TNF-α peaks during implantation (weeks 6-8) coincide with maternal thyroid adaptation requirements