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139 Other inhibitors are also emerging, such as caudatan A, a novel human kidney-type glutaminase inhibitor with tetracyclic flavan, isolated from Ohwia caudata
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Overexpression of the rate‐limiting ribosome recycling factor ABCE1 or knockdown of ZNF598, which cause inefficient RQC and therefore resumption of translation by the stalled ribosome, can rescue the proteostasis failure, endolysosomal/autophagy dysfunction, and cognitive deficits in AD mouse models [99]
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