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[31] Accordingly, the present disclosure provides a myostatin-selective inhibitor for use in the treatment of a metabolic disorder in a patient, wherein the treatment comprises administration of the myostatin-selective inhibitor to the patient alone or in conjunction with an additional agent, such as a GLP-1 pathway activator (e.g., a GLP-1 receptor agonist), in amounts effective to treat the metabolic disorder, wherein the myostatin-selective inhibitor is any one of the antibodies or antigen-binding fragment thereof described herein