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Type IV Hypersensitivity Reaction | Concise Medical Knowledge

In addition to this canonical signaling from the plasma membrane, IGF-1R can be modified by the addition of small ubiquitin-like modifier proteins (sumoylation) that enable it to translocate to the nucleus, where it can interact with chromatin and regulate gene transcription [43–46]

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Br J Clin Pharmacol 2012;73(2):170-4

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