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Glossary 5-HT1A 5-hydroxytryptamine receptor 5-HT2 5-hydroxytryptamine (serotonin) receptors AD Alzheimer’s disease ADAS-Co g Alzheimer’s Disease Assessment Scale–Cognitive Subscale Akt Protein kinase B AMPK AMP-activated protein kinase APOE Apolipoprotein E APP Amyloid precursor protein Aβ Amyloid-β AβO Aβ oligomers BBB Blood-brain barrier Bcl-2 B-cell lymphoma two BDNF Brain-Derived Neurotrophic Factor CA1 Cornu ammonis CaMK calmodulin-dependent protein kinase CIN Chromosome Instability CKII Casein kinase II CNTs Carbon nanotubes CREB Cyclic AMP response element-binding protein CSF Cerebrospinal Fluid CSNK2B Casein Kinase 2, Beta Subunit DG Dentate gyrus EGCG Epigallocatechin gallate EGR-1 Early growth response protein 1 ERK Extracellular regulated kinase GBE Ginkgo biloba extract GRIN1 Glutamate Ionotropic Receptor NMDA Type Subunit 1 GSK3β Glycogen synthase kinase-3β HFFD High-fat and high-fructose diet IRS-1 Insulin receptor substrate-1 JNK c-Jun-N-terminal kinase LTD long-term depression LTP long-term potentiation MAPK1 Mitogen-activated protein kinase 1 MCI Mild cognitive impairment MD molecular dynamics MDA Malondialdehyde MMSE Mini-Mental State Examination mTOR Mammalian target of rapamycin NEP Neprilysin NF-κB Nuclear factor kappa B NGF Nerve growth factor NMDA N-methyl-D-aspartate NSCs Neural stem cells NT-3 Neurotrophin 3 PDB Protein Data Bank PET positron emission tomography PI3K Phosphoinositide 3-kinase PKC Protein kinase C PLCγ2 Phospholipase Cγ2 PS1 Presenilin-1 PSD95 Postsynaptic density protein 95 QDs Quantum dots RCTs Randomized Controlled Trials rTg4510 Regulatable Transgenic 4,510 SGZ sub granular zone of the dentate gyrus SIRT1 Sirtuin-1 SKT Short Cognitive Performance Test SNARE soluble N-ethylmaleimide-sensitive factor attachment protein receptor SOD Superoxide dismutase SVZ sub ventricular lining the lateral ventricles zone SYN Synaptophysin TGF-β1 Transforming growth factor beta-1 TNF-α Tumor necrosis factor-alpha TrkB Tropomyosin receptor kinase B UPI utero-placental insufficiency Val66Met Valine-66-Methionine wnt Wingless-related kinase β-catenin Beta-catenin References 1 AbdulkhaliqA

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The strong adjuvant in the HPV vaccine caused the bursitis to be unresponsive to corticosteroid injections, leading to chronic severe inflammation evident during arthroscopy