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APAP-induced hepatotoxicity is thought to lead mainly to hepatocyte necrosis, but studies on the intracellular signaling mechanism underlying cell death suggest that both apoptosis and necroptosis may be involved (Ramachandran and Jaeschke, 2019)

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These G protein-coupled receptors (Waldhoer et al., 2004) undergo conformational changes upon heroin binding, thereby inhibiting adenylate cyclase activity, reducing cAMP production (Tedford and Zamponi, 2006), and subsequently impairing neuronal signaling (Figure 3)