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The ECS is made up of G protein-coupled cannabinoid receptors CB 1 and CB 2 [36], their endogenous ligands such as classical endocannabinoids (e.g., anandamide or N-arachidonoylethanolamine and 2-arachidonoylglycerol) and endocannabinoid-like compounds (e.g., PEA, oleoylethanolamide—OEA, and stearoylethanolamide—SEA) [37], and the metabolic enzymes responsible for endocannabinoid synthesis and degradation [38]
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