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They form a highly dynamic entity, continuously transmitting signals to the individual components that undergo a series of regulations to enhance or modulate the integrity of the intestinal barrier

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However, it can now be seen that the barrier contribution to toxicity is much more likely to be due to greater transport by, e.g., Slc1a4, see Table 4, which summarizes data on expression of influx transporters and published reports on transport function in the developing brain