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2.6 Measurement of 5-FU and folinic acid in plasma and tumor using LC-MS Furthermore, in order to monitor the steady state plasma levels of FOLFOX component drugs in HCT-116 xenograft-bearing mice, at the end of FOLFOX and/or PV treatment, a batch of mice received intravenous injection of FOLFOX, blood and tumor tissues were collected 15 min after the FOLFOX administration
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