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5 The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China *These authors contributed equally to this work Correspondence: Yuanyuan Wu, Email [email protected] Jianqiao Fang, Email [email protected] Introduction: Trigeminal neuralgia (TN) is a severe neuropathic pain disorder characterized by unpredictable pain paroxysms, significantly impairing patients’ quality of life through associated anxiety and depression