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demonstrated a positive correlation between serum butyric acid levels and PD-1 expression on circulating CD8+ and V2+ T lymphocytes in NSCLC patients ( Previous studies have demonstrated that SCFAs, especially butyrate, stimulate the generation of regulatory T cells (Treg cells) outside the thymus, contribute to the development of Treg cells in the colon, and are regulated by HDAC (143–145)
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Acknowledgements The authors express gratitude to Mr Derrick Maxwell for his competent technical assistance with the Instron 5848 Microtester
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