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However, at least part of the immune response to IL-5 in mice is NOT part of the biological effect in humans, i.e., in mice, IL-5 enhances several functions of B cells, including immunoglobulin production, growth, and differentiation, whereas human B-cells are influenced by IL-5 only in the presence of specific cytokines and under certain conditions.20 However, human IL-5 does act on T cells by increasing the expression of IL2Rα and augmenting cytotoxic T cell generation.23 Eosinophil development occurs as a result of functional interactions among various transcription factors.24 The key transcription factors involved in eosinophil lineage commitment and terminal differentiation are GATA-1, FOG-1 (friend of GATA-1), C/EBPα (CCAAT enhancer-binding protein α), and the ets (E-twenty six) family transcription factor, PU.1.4 GATA-1 functions primarily to facilitate the differentiation of granulocyte–macrophage progenitors into eosinophils