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In a vitamin B6 deficiency-induced hepatic fat deposition model, betaine exhibited a significant inhibitory effect and restored methionine metabolism and very low-density lipoprotein secretion, the mechanisms of which may be associated with the restoration of the phosphatidylethanolamine-to-phosphatidylcholine conversion pathway (81, 82)
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In cases of mild to moderately active ‘CD, alterations in tight junction structure and barrier dysfunction were associated with downregulation of claudins-5 and −8 and an upregulation of claudin-2 [90]
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