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Finally, unlike high-molecular-weight polysaccharides, ergothioneine acts as a small molecule that is actively transported by the OCTN1 carrier, accumulating in the brain and cerebrospinal fluid, as confirmed by radiolabeled distribution studies showing its uptake within the central nervous system [138]
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Next, using oligodendrocyte and APOE4-expressing oligodendrocyte cultures, they found that APOE4 in oligodendrocytes contributes to cellular cholesterol accumulation and diminished fluorescence intensity of MBP [78]
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