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In further embodiments, the invention encompasses a method of modulating stem cell differentiation by contacting a stem cell expressing NNMT with one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c′, 1f′, 1l′, 1m′, 2j′, 2k′, 2l′, 2m′, and 2aa′
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labs, a serum B12 below about 200 pg/mL (148 pmol/L) points to deficiency, while 200–300 pg/mL is a borderline “gray zone” that often needs a confirmatory MMA or active B12 test
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